Oral Applications

The gastrointestinal (GI) tract is a physiological and chemical barrier and therefore presents complex demands for oral therapy. The fact that approximately 50% of newly developed active ingredients are poorly soluble or completely insoluble in water leads to additional challenges due to their low absorption rates and low bioavailability. It is extremely difficult to develop potent formulations with these active ingredients. A common approach is the use of dissolution techniques, excipients and lipids.

Phospholipid-based formulations can positively affect the absorption of active ingredients through the following mechanisms:

Modification of drug release;
Increased bioavailability;
Modification of the composition and therefore the character of the intestinal environment;
Stimulation of lymphatic transport;
Interaction with enterocyte-based transport processes;
Reduction of unwanted side effects of the drug;

Lipoid offers a wide range of purified lecithins and phospholipids tailored for oral pharmaceutical applications. All types of drug delivery systems such as liposomes, emulsions, mixed micelles, solid lipid nanoparticles and suspensions can be prepared with these unique excipients.